Kanoski lab memory tasks: object-location novelty preference
The lab also uses non-food memory tasks: animals placed in an arena preferentially investigate objects they haven't seen in a new location, testing object-location memory.
Results
WHY · 797 of 37380 results · Fuel
Measuring dopamine: PET in humans and fiber photometry in animals
Dopamine can be measured in humans via PET imaging as a proxy of dopamine binding in the brain, and the guest's lab uses dopamine sensors with fiber photometry to record dopamine release in awake, behaving animals.
Adipocytes respond to insulin by taking up glucose
When adipocytes (fat cells) detect insulin, they turn on a protein that causes glucose to be taken up into the fat cell.
described
Host would pay more for blueberries with 10x polyphenols
Andrew Huberman states that provided it was safe, he would love to eat a bowl of blueberries with 10 times as many polyphenols and would pay more for those blueberries. This is a personal anecdote illustrating demand for more nutrient-dense whole foods.
Personal preference, anecdotal.
Lidocaine use in breast cancer surgery is associated with lower recurrence
Huberman relays David Fagenbaum's highlight that in breast cancer surgeries where lidocaine was used, the incidence of recurrence is significantly lower, apparently due to lidocaine's effect on the local environment; he explicitly notes this is not his own work.
quoted
Understanding metabolism matters more than hunting for peptides
Huberman notes that when people hear acronyms they don't understand, they get overwhelmed — but understanding metabolism and energy production is important whether young or old, healthy or dealing with cancer. When people hear about a molecule being discovered, they immediately ask if there is a peptide for it; he suggests holding off and thinking about how we come to understand these essential aspects of ourselves. He also walks through what is needed before discovering a protein like MPC: cells, the ability to find the mitochondria, and the ability to know what's ATP and what's pyruvate.
Consequential creator advice requires independent verification before Today can promote it.
The essence of a lobster roll: emphasize a wonderful natural ingredient, don't transform it
The creator's philosophy: the recipe is deliberately simple — basically mayonnaise, lemon, salt, and a little chive — just seasoning up the delicious shrimp. The essence of a lobster roll is having a really wonderful natural ingredient and emphasizing its beauty rather than changing it into something else. The finished salad is plump, sweet, a little juicy and flaky, with nothing stepping on the shrimp; a minimalist seafood experience that reminds him of the East Coast.
Rutter's lab journey to the MPC discovery
Around 2008-2009, Rutter's laboratory became fascinated with mitochondria after realizing many proteins in mitochondria were known to exist but their functions were unknown. The discovery of the mitochondrial pyruvate carrier was a fun time in his career and one of its highlights, fueled by the brilliant people in his lab.
A YouTube subscriber taught him about cinnamon types
One of Jesse's YouTube subscribers pointed out the difference between cassia and Ceylon cinnamon to him a long time ago.
Late-night training and post-training dinner
Jesse doesn't work out until very late at night and doesn't have dinner until after training, which could be 11 or 11:30 PM.
Italian upbringing and the seven fishes
Jesse grew up as an Italian kid whose grandfather prepared the seven fishes on Christmas Eve, which is why he eats pasta.
Smaller-cut shrimp tasted like chicken salad, not a lobster roll
The creator tried variations where he cut the shrimp smaller, even chopping half of them into more of a shrimp-salad texture. It was really good, but it wasn't shrimp-roll or lobster-roll-esque — it tasted more like chicken salad with a kind of pastiness, and didn't work in a roll (though it would be good on a bun).
Apigenin is a derivative of chamomile
Apigenin (A-P-I-G-E-N-I-N) is a derivative of chamomile.
Caffeine at lower doses is a reasonable stimulant entry point; some experience anxiety on potent stimulants
Huberman notes that caffeine, at lower dosages than found in coffee and tea, is a reasonable way to explore stimulant-based approaches for enhancing cognitive function and focus. He also describes that some people experience a lot of anxiety on a potent stimulant supplement, possibly because they take it on an empty stomach or with subcaloric diets.
Medicine reads signs from body outputs, surface appearance, and internal imaging — each channel gives different information
Andrew Huberman describes that medicine has a couple of different ways to determine what's going on: what comes out of the body (mucus color, bowel movements), what's visible on the surface (skin pallor, eye appearance), and what requires internal imaging — each channel gives different information.
Fluorescein drops create contrast for eye surgeons
Dr. Chris Thompson describes how fluorescein drops create contrast that helps eye surgeons distinguish healthy from unhealthy tissue and avoid cutting the wrong tissue.
Endoscopic ultrasound images are grayscale; blood flow can be toggled on
Dr. Chris Thompson explains that endoscopic ultrasound images are all shades of gray with no color, so contrast and structure differences are what you rely on — and a button can be turned on to see blood flow.
Why HIIT mobilizes visceral fat: receptors and acute stress
Dr. Thompson explains that visceral fat has beta adrenergic receptors and gonadotropic hormone receptors on it, making it responsive to acute stress, so it will mobilize during the stress of high intensity interval training. However, fat mobilized during HIIT is not burned right away because you're burning carbs — liver glycogen and muscle glycogen — at the time.
Constipation in women may involve psychological, immune, neural, and endocrine factors
Dr. Sara Gottfried suggests that constipation in women may relate to psychology, immunology, neural and endocrine factors combined, including perceived stress and borderline thyroid function.
hedged
Hippocampus-lesioned rodents cannot learn that energy restriction predicts events
Normal rodents can learn that a high level of energy restriction predicts an upcoming event like a foot shock or food pellet, but hippocampus-lesioned animals cannot.
animal evidence
Protocols you can run
WHY · 2 of 61 published protocols · Fuel
Morning Hydration Protocol
Upon waking, before anything else, drink 16 to 20 ounces of water. This single, timed action is directly instructed by the creator with no missing details.
Take Daily Targeted Supplements
Take a methylated B vitamin complex daily if you have the MTHFR mutation.
Source analyses
WHY · 11 of 697 current source analyses · Fuel
People worth following for this
The creators behind most of what cleared in Fuel.
WHY · 3 creators you don't follow account for 797 cleared insights · Fuel
- Andrew Huberman
698 cleared insights match
- ATHLEAN-X™
77 cleared insights match
- Brian Lagerstrom
22 cleared insights match
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